MCF Spring Meeting Info

Spring Quarterly Meeting

Coupling Laboratory Animals to Liquid Chromatography Using Microdialysis Probes and Robotic Blood Sampling. Pharmacokinetics, Pharmacodynamics, LC/MSMS and LC/EC

By Dr. Peter Kissinger
President, Bioanalytical Systems (BAS)

Date:	Thursday, April 19, 2001
Location:	Holiday Inn, St. Paul East I-94 & McKnight Road N 2201 Burns Ave.

Abstract:

In the preclinical phase of drug development it is inevitable that animal studies must be accomplished to understand such issues as drug safety, drug metabolism, oral absorption (if any), blood brain barrier penetration (if any), the rate of excretion, the effect on behavior (CNS effects), and so forth. Bioanalytical chemistry is crucial to gaining an understanding. Samples must be taken and compounds must be quantitated, including the drug substance and any metabolites, as well as endogenous substances the drug candidate might influence. We have been developing sampling approaches which reduce animal stress, improve data quality, and reduce the number of animals required to get to a satisfactory result (this reduces cost and speeds the drug candidate to the next steps). This presentation will illustrate this integrated approach in which liquid chromatography, mass spectrometry, and electrochemistry are coupled to sampling in a more automated fashion than was possible even a just a few years ago. Components of the approach also include 96-well SPE, the Raturn animal containment system, the Culex robotic blood sampler, and epsilon microbore liquid chromatography.

The Speaker ...

Peter Kissinger received his B.S. from Union College in 1966 and his Ph.D. from the University of North Carolina in 1970. After spending time at the University of Kansas and Michigan State University, he moved to Purdue and later founded Bioanalytical Systems, a pharmaceutical development company doing contract research and supplying products for medical research. BAS has played a part in the development of drugs that now sell at over $15B/year for major pharmaceutical companies. Over the years he has given over 400 invited lectures and published over 200 manuscripts. he is probably best known for the development of chromatographic methodology for determining drugs and endogenous small molecules in tissue and biological fluids. His current work in liquid chromatography continues with a strong focus on the development of LC/MSMS for neuroscience, drug metabolism and pharmacokinetics. when not doing chromatographic work you can find Peter pursuing other ventures, including bee keeping.

For additional information or directions contact Paul Jackson.

Everyone is welcome!